Journal article
Early pregnancy vitamin d binding protein is independently associated with the development of gestational diabetes: A retrospective cohort study
M Fernando, SJ Ellery, D de Guingand, C Marquina, S Lim, CL Harrison, HJ Teede, N Naderpoor, A Mousa
Journal of Clinical Medicine | Published : 2020
DOI: 10.3390/jcm9072186
Abstract
Background: Vitamin D-binding protein (VDBP) has been implicated in several adverse pregnancy outcomes either directly or indirectly via influencing the concentrations of biologically active vitamin D metabolites. However, human studies exploring these metabolites in pregnancy remain sparse. Here, we examine whether VDBP and total, free, and bioavailable 25-hydroxyvitamin D (25(OH)D) metabolites in early pregnancy are associated with subsequent adverse pregnancy outcomes. Methods: We conducted a retrospective analysis of 304 pregnant women in early pregnancy (<20 weeks gestation). The demographic characteristics, anthropometric data, and total 25(OH)D were measured and plasma or serum sample..
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Funding Acknowledgements
As part of a larger study of biomarker analyses, funding for this work was provided by a secondment grant from the National Health and Medical Research Council (NHMRC) Centre for Research Excellence in Polycystic Ovarian Syndrome and a clinical exercise science seed grant from the Institute of Sport, Exercise and Active Living, Victoria University. AM, SJE and SL are funded by Biomedical fellowships provided by the NHMRC. HJT is a NHMRC Medical Research Future Fund Practitioner Fellow.